Uddanam Kidney Disease Study Reveals Key Findings.. Experts Probe Possible Causes

A comprehensive study is underway in the Uddanam region of Srikakulam district to investigate the long-standing prevalence of kidney diseases and identify their possible causes. Of the 5,851 people targeted for the study, 3,897 individuals across four mandals have been screened so far. Kidney-related problems were identified in 949 people, accounting for 24.35 percent of those examined. Among them, 550 were found to have chronic kidney disease (CKD), while 399 were diagnosed with chronic kidney disease of unknown etiology (CKDu). The highest number of CKD and CKDu cases was reported from Kaviti mandal.

The study is examining several possible factors, including genetic, environmental and occupational influences. Researchers are collecting blood and urine samples from residents at their homes and testing kidney function and early biomarkers that may help identify people at risk. Soil and water samples are also being examined for pesticide residues, heavy metals and other possible contaminants. RNA sequencing and genetic factors are being studied as well. The interim findings have been submitted to the ICMR, while experts have stressed that final conclusions can be drawn only after completing the remaining fieldwork and combining the results with environmental and biomarker analyses. The three-year study has been approved by the ICMR and Department of Health Research, with a budget of Rs. 6.2 crore.